Abstract #3775
Elevated glutamate levels in the visual cortex of patients with Migraine detected at 7 Tesla
Jannie P Wijnen 1,2 , Ronald Zielman 3 , Andrew Webb 2 , Gisela M Terwindt 3 , Michel Ferrari 3 , Hermien E Kan 2 , and Mark C Kruit 2
1
Radiology, University Medical Centre
Utrecht, Utrecht, Utrecht, Netherlands,
2
Radiology,
Leiden University Medical Centre, Leiden, Netherlands,
3
Neurology,
Leiden University Medical Centre, Leiden, Netherlands
In this study we assessed the interictal (between
attacks) glutamate levels of migraine patients and
compared the levels to age and gender matched healthy
controls. Ultra high field Magnetic Resonance
Spectroscopy (7 Tesla) of the visual cortex was
performed in 20 patients and 20 controls. Linear
regression of between subject effects was performed on
the glutamate concentration with the fraction of gray
matter (GM) in the voxel as covariate. This analysis
revealed elevated interictal glutamate levels in
patients with migraine. At ultra high field, glutamate
can be robustly detected, which opens opportunities to
study the role of glutamate in migraine in more detail.
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