Abstract #3779
2D L-COSY at 7T Detects Glutamate, Glutamine, Glutathione and GABA in Patients with Schizophrenia
Gaurav Verma 1 , David Roalf 2 , Ruben Gur 2 , Raquel Gur 2 , and Harish Poptani 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Psychiatry,
University of Pennsylvania, Philadelphia, PA, United
States
Irregularities in cortical glutamate, glutamine,
glutathione and gamma-aminobutyric acid (GABA) have been
correlated with symptoms of schizophrenia, yet these
spectral overlap with nearby resonances makes these
metabolites difficult to resolve. Two-dimensional (2D)
localized correlated spectroscopy (L-COSY) at 7T
facilitates the unambiguous detection of these
metabolites. Twelve subjects (six patients, six
controls) were scanned with L-COSY at 7T. Glutamate,
glutamine, glutathione and GABA were reliably detected
using L-COSY with coefficients of variation of 20% or
below and Glutathione was found to be significantly
higher in the patient group. L-COSY could have potential
application in monitoring treatment response in
schizophrenia patients.
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