Abstract #3780
Glutamatergic changes detected upon functional activation with a Stroop Task in healthy controls and in subjects with Schizophrenia
Reggie Taylor 1,2 , Betsy Schaefer 3 , Richard Neufeld 3 , Peter Williamson 1,3 , and Jean Theberge 1,2
1
Medical Biophysics, Western University,
London, ON, Canada,
2
Lawson
Health Research Institute, London, ON, Canada,
3
Psychiatry,
Western University, London, ON, Canada
The glutamatergic response to functional activation in
the anterior cingulate cortex (ACC) was examined in 14
healthy controls (HC), 14 subjects with schizophrenia
(SZ), and 10 subjects with mood disorder. The ACC was
activated using a Stroop task, which is known to
activate the area, and the glutamatergic response was
monitored using 1H-MRS. Significant (p<0.05) increases
were observed in both HC and SZ groups, but not the mood
group. This ongoing study is the first to report on the
ability of patients with SZ to dynamically regulate
their levels of ACC Glu.
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