Abstract #3781
Subcortical Glutamate Increase Suggestive of Glial Toxicity in Depressed patients with High Inflammation
Li Wei 1,2 , xiaoping Hu 1,2 , Andrew H Miller 2,3 , and Ebrahim Haroon 2,3
1
Biomedical Imaging Technology Center, Emory
University, Atlanta, GA, United States,
2
School
of Medicine, Emory University, Atlanta, GA, United
States,
3
Winship Cancer Institute, Atlanta,
GA, United States
Chronic immune activation forms the basis of many
medical and behavioral disorders. The mechanism of the
association between immune changes and behavior disorder
is not clear. We hypothesize that the link might reside
in the metabolism of glutamate, an excitatory amino
acide neurotransmitter. Interestingly unbridled increase
in glutamate concentration might result in
neurodegenwerative and behavioral changes. We studied 9
depressed patients with high inflammation and compared
them to 15 patients who had depression with low
inflammation. We measured glutamate concentrations in
the bilateral basal ganglia using chemical shift imaging
(MRS). Depressed patients with high inflammation had
significantly increased concentrtion of glutamate/creatine,
choline/creatine and inositol/creatine that supporting
our intial hypothesis.
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