Abstract #3782
Anterior Cingulate Glutamate Concentrations as a Window to Study Impact of Inflammation on Behavior
Xiangchuan Chen 1 , Xiaoping Hu 1 , Andrew H. Miller 2,3 , and Ebrahim Haroon 2,3
1
Biomedical Imaging Technology Center, Emory
University, Atlanta, GA, United States,
2
School
of Medicine, Emory University, Atlanta, GA, United
States,
3
Winship Cancer Institute, Atlanta,
GA, United States
Increased neural and glial activity in several brain
regions including dorsal anterior cingulate cortical
(dACC) regions has been reported to occur in response to
inflammatory activation by infections, cancer and
chronic psychological stress. We designed a study to
test the hypothesis that depressed patients with CRP >
3mg / L (high inflammation) will show an increase in the
dACC glutamate and inositol levels indicating high
levels of neuronal and glial activation and further that
the neural metabolite changes will be directly and
positively correlated with inflammatory biomarkers seen
in plasma.
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