Abstract #3785
MR Proton Spectroscopy study in nocturnal frontal lobe epilepsy
Caterina Tonon 1 , Laura Ludovica Gramegna 1 , Ilaria Naldi 2 , Claudia Testa 1 , David Neil Manners 1 , Giovanni Rizzo 1 , Lorenzo Ferri 2 , Claudio Bianchini 1 , Francesca Bisulli 2,3 , Paolo Tinuper 2,3 , and Raffaele Lodi 1
1
Functional MR Unit, Department of Biomedical
and NeuroMotor Sciences (DiBiNeM), University of
Bologna, Bologna, Italy,
2
Department
of Biomedical and NeuroMotor Sciences (DiBiNeM),
University of Bologna, Bologna, Italy,
3
Institute
of Neurological Sciences of Bologna, Bologna, Italy
Nocturnal frontal lobe epilepsy (NFLE) is a syndromic
entity that includes paroxysmal episodes appearing
almost exclusively during sleep. The study used 1H-MRS
to evaluate the possible involvement in NFLE of the
anterior cingulated cortex, which is considered to have
inhibitory function on spontaneous motor activity.
Spectra were acquired in the anterior cingulated cortex
using single voxel PRESS (TR/TE=4000/35). In the
anterior cingulated cortex of patients NAA/Cr was lower
than in healthy controls (p<0.01). NAA/Cr values
correlated negatively with clinical severity of NFLE
(beta: -0,473, p<0.05). Our results point to a role of
anterior cingulated cortex dysfunction in the NFLE
pathophysiology
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