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Abstract #3790

Distribution of sodium concentration in brain using sodium MRI and double inversion recovery proton MRI

Guillaume Madelin 1 , Richard Kline 2 , Ronn Walvick 1 , Christopher Glielmi 3 , Dominik Paul 4 , Heiko Meyer 4 , Mony de Leon 5 , Henry Rusinek 1,5 , and Ravinder R Regatte 1

1 Radiology, New York University Langone Medical Center, New York, NY, United States, 2 Anesthesiology, New York University Langone Medical Center, New York, NY, United States, 3 Siemens Medical Solutions USA, Inc, New York, NY, United States, 4 Siemens AG, Erlangen, Germany, 5 Psychiatry, New York University Langone Medical Center, New York, NY, United States

A combined 1H-23Na MRI method was implemented at 3T for measuring apparent total and intracellular sodium concentrations (aTSC, aISC) in gray and white matter (GM, WM) in brain in vivo. Sodium images were acquired with and without fluid suppression by inversion recovery. A double inversion recovery (DIR) sequence (1H) was used to create masks of GM and WM which were applied to the sodium data. Statistical parameters of distributions of aTSC and aISC values are measured in GM and WM and revealed non-Gaussian shape. This MRI method has potential for assessing early metabolic information in neurodegenerative pathologies non-invasively.

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