Abstract #3791
Single-shot Acquisition of [1-13C]Pyruvate and Lactate on a 3T Clinical Scanner
Benjamin J. Geraghty 1,2 , Justin Y. C. Lau 1,2 , Albert P. Chen 3 , and Charles H. Cunningham 1,2
1
Dept. of Medical Biophysics, University of
Toronto, Toronto, Ontario, Canada,
2
Physical
Sciences, Sunnybrook Research Institute, Toronto,
Ontario, Canada,
3
GE
Healthcare, Toronto, Ontario, Canada
Simultaneous acquisition of multiple hyperpolarized 13C
metabolites within a single-shot is possible through
jointly sampling k-t space with a spiral trajectory that
oversamples the field-of-view, and has been demonstrated
on a small animal scanner. Due to limited gradient
performance in conventional clinical scanners, achieving
large oversampling rates while maintaining adequate
resolution within a single readout is unfeasible. We
relax the oversampling requirement by selectively
exciting only two metabolites using a dual-band
spectral-spatial pulse. Images are recovered through a
model based least squares reconstruction. In vivo
feasibility of simultaneous acquisition of
hyperpolarized [1-13C]pyruvate and lactate is
demonstrated on a healthy rat.
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