Abstract #3797
Assessment of acute inflammatory liver injury in a rat CCl4 model using metabolic imaging of hyperpolarized [1-13C]pyruvate
Sonal Josan 1,2 , Kelvin Billingsley 1,3 , Juan Orduna 2 , Jae Mo Park 1 , Richard Luong 4 , Srinevas Reddy 5 , Ralph Hurd 6 , Adolf Pfefferbaum 2,7 , Daniel Spielman 1 , and Dirk Mayer 1,8
1
Radiology, Stanford University, Stanford,
CA, United States,
2
SRI
International, Menlo Park, CA, United States,
3
Chemistry
and Biochemistry, San Francisco State University, San
Francisco, CA, United States,
4
Comparative
Medicine, Stanford University, Stanford, CA, United
States,
5
Surgery,
University of Maryland, Baltimore, MD, United States,
6
GE
Healthcare, CA, United States,
7
Psychiatry
and Behavioral Sciences, Stanford University, Stanford,
CA, United States,
8
Diagnostic
Radiology and Nuclear Medicine, University of Maryland,
Baltimore, MD, United States
Numerous studies using hyperpolarized pyruvate (Pyr)
have been applied to investigate cancer and heart
disease, but very few reports have been published on
applications in diseased liver other than cancer. As
several liver pathologies are associated with elevated
alanine transaminase (ALT) activity, the aim of this
work was to investigate the use of dynamic metabolic
imaging of hyperpolarized [1-13C]Pyr for the assessment
of liver damage induced by administration of carbon
tetrachloride (CCl4).
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