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Abstract #3802

Improved dynamic 3D spiral CSI with interleaved spectral band excitation for metabolic imaging of hyperpolarized [2-13C]pyruvate

Sonal Josan 1 , Jae Mo Park 1 , Ralph Hurd 2 , Daniel Spielman 1 , and Dirk Mayer 1,3

1 Radiology, Stanford University, Stanford, CA, United States, 2 GE Healthcare, CA, United States, 3 Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States

There has been growing interest recently in using hyperpolarized [2-13C]pyruvate, to follow the 13C label into metabolic products including glutamate (in exchange with α-ketoglutarate in the TCA cycle), citrate, and acetylcarnitine as well as lactate and alanine. CSI with [2-13C]Pyr is challenging given the wide spectral dispersion of the resonances. This work presents an improved design for 3D CSI with [2-13C]Pyr using spectrally selective excitation of limited frequency bands containing a subset of metabolites, and interleaving different bands to acquire dynamic metabolic data in vivo in rat liver.

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