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Abstract #3801

Measuring polarization using asymmetry of hyperpolarized [1,2- 13 C]Pyr doublets

Keshav Datta 1 , Sonal Josan 2 , and Daniel Spielman 2

1 Dept. of Electrical Engineering, Stanford University, Stanford, CA, United States, 2 Department of Radiology, Stanford University, Stanford, CA, United States

Knowledge of the liquid-state polarization is necessary for absolute quantitation of in vivo hyperpolarized MRS data. In contrast to earlier work suggesting asymmetry of the C2 doublet (aC2) of [1,2-13C]Pyr (1% naturally abundant in a hyperpolarized [1-13C]Pyr sample) can directly be used to compute the instantaneous polarization, we present both analytic expressions and experimental results demonstrating a single measurement of aC2 is insufficient, and polarization calculations also depend on both the delay between the sample exiting the polarizer and the time of measurement as well as knowledge of the T1 decay rates of the individual peaks in the doublet resonance.

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