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Abstract #3805

Interleaved Imaging and Frequency-Selective Spectroscopic Acquisition for in vivo Pyruvate Polarization Monitoring

Justin Y. C. Lau 1,2 , Albert P. Chen 3 , Jennifer Barry 2 , William Dominguez-Viqueira 2 , and Charles H. Cunningham 1,2

1 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 2 Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, 3 GE Healthcare, Toronto, Ontario, Canada

The feasibility of interleaved imaging and selective spectroscopic acquisition for hyperpolarized 13 C is demonstrated in vivo . The asymmetry of the pyruvate C 2 doublet has been shown to correlate with the instantaneous polarization. Combined with a calibration-based interpretation of measured C 2 asymmetry, this investigation is a promising step toward hyperpolarized signal intensity normalization for quantitative in vivo metabolic image analysis.

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