Abstract #3806
Effects of acute and chronic dichloroacetate treatment on hyperpolarized 13 C pyruvate metabolism, necrosis and tumor volume in P22 sarcoma bearing BDIX rats
Steven Reynolds 1 , Tooba Alizadeh 2 , Stephen Metcalf 2 , Adriana Bucur 1 , Samira Kazan 2 , Becky Bibby 2 , Martyn Paley 1 , and Gillian M Tozer 2
1
Academic unit of radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom,
2
Tumor
microcirculation group, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom
Hyperpolarized
13
C-pyruvate
MRS/MRI was used to study the effect of dichloroacetate
(DCA), which disrupts pyruvate dehydrogenase kinase, on
tumor metabolism. We used acute DCA dosing (30 minutes
prior to scanning) and chronic DCA dosing (up to 10
daily doses) in P22 sarcoma-bearing BDIX rats. MR data
showed no significant difference between treated and
control groups for the pyruvate to lactate rate constant
k
pl
in
either the acute or chronic cohorts. There were also no
significant differences in tumor growth rate or
percentage cell necrosis. However, pyruvate
concentration was decreased in tumors treated
chronically with DCA versus control.
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