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Abstract #3806

Effects of acute and chronic dichloroacetate treatment on hyperpolarized 13 C pyruvate metabolism, necrosis and tumor volume in P22 sarcoma bearing BDIX rats

Steven Reynolds 1 , Tooba Alizadeh 2 , Stephen Metcalf 2 , Adriana Bucur 1 , Samira Kazan 2 , Becky Bibby 2 , Martyn Paley 1 , and Gillian M Tozer 2

1 Academic unit of radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Tumor microcirculation group, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Hyperpolarized 13 C-pyruvate MRS/MRI was used to study the effect of dichloroacetate (DCA), which disrupts pyruvate dehydrogenase kinase, on tumor metabolism. We used acute DCA dosing (30 minutes prior to scanning) and chronic DCA dosing (up to 10 daily doses) in P22 sarcoma-bearing BDIX rats. MR data showed no significant difference between treated and control groups for the pyruvate to lactate rate constant k pl in either the acute or chronic cohorts. There were also no significant differences in tumor growth rate or percentage cell necrosis. However, pyruvate concentration was decreased in tumors treated chronically with DCA versus control.

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