Abstract #3808
Axonal transport rate decreased at the onset of optic neuritis in EAE mice
Tsen-Hsuan Lin 1 , Joong Hee Kim 2 , Carlos Perez-Torres 2 , Chia-Wen Chiang 2 , Kathryn Trinkaus 3 , Anne H. Cross 4,5 , and Sheng-Kwei Song 2,5
1
Physics, Washington University, St. Louis,
MO, United States,
2
Radiology,
Washington University School of Medicine, St. Louis, MO,
United States,
3
Biostatistics, Washington
University School of Medicine, St. Louis, MO, United
States,
4
Neurology,
Washington University School of Medicine, St. Louis, MO,
United States,
5
The
Hope Center for Neurological Disorders, Washington
University School of Medicine, St. Louis, MO, United
States
Axonal transport plays a crucial role in
neurodegenerative diseases. However, few reports have
assessed axonal transport rate in MS or in experimental
autoimmune encephalomyelitis (EAE). To assess the
integrity of axonal transport in EAE, we employed the
widely used manganese-enhanced MRI (MEMRI) on EAE mice
at the onset of optic neuritis. Our results reveal that
the axonal transport rate in EAE mice at the optic
neuritis onset was significant decreased compared with
the sham mice and correlated well with severity of
impaired visual function. Postmortem
immunohistochemistry was performed to assess optic nerve
pathologies, including axonal injury, demyelination, and
inflammation.
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