Abstract #3809
Not All Brain Regions Are Created Equal: Insights From Longitudinal Imaging of Early Postnatal Mouse Brain Development.
Kamila U Szulc 1,2 , Jason P Lerch 3 , Brian J Nieman 3 , Benjamin B Bartelle 1,4 , Edward J Houston 1 , Giselle A Suero-Abreu 1,2 , Miriam Friedel 3 , Charles Watson 5 , Alexandra L Joyner 6 , and Daniel H Turnbull 1,7
1
Kimmel Center for Biology and Medicine at
the Skirball Institute of Biomolecular Medicine, NYU
School of Medicine, New York, NY, United States,
2
Biomedical
Imaging Graduate Program, NYU School of Medicine, New
York, NY, United States,
3
Mouse
Imaging Centre, Hospital for Sick Children, Toronto, ON,
Canada,
4
Molecular
Biophysics Graduate Program, NYU School of Medicine, New
York, NY, United States,
5
The
Australian Mouse Brain Mapping Consortium, The
University of Queensland, Brisbane, QLD, Australia,
6
Developmental
Biology Program, Sloan-Kettering Institute, New York,
NY, United States,
7
Departments
of Radiology and Pathology, NYU School of Medicine, New
York, NY, United States
Lacking among the currently available set of MRI
techniques has been an imaging approach that would allow
for 3D noninvasive, longitudinal studies of brain
development in individual mice. The goal of this project
was to develop and optimize a Mn-enhanced MRI (MEMRI)
imaging approach and to create a comprehensive database
of normal mouse brain development to serve as a
reference for future studies of mouse models of
neurodevelopmental disorders. Through this work we were
able to show that different brain regions are
characterized by unique growth rates and patterns, which
are accompanied by brain-region specific changes in
MEMRI signal intensity.
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