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Abstract #3810

In vivo molecular imaging using a dual-imaging reporter gene for verifying the role of HOXA gene subfamily in gastric cancer development and therapeutic monitoring

Chiao-Yun Chen 1,2 , Twei-Shiun Jaw 1,2 , Deng-Chyang Wu 2,3 , Yun-Ming Wang 4 , Gin-Chung Liu 1,2 , Kazunari K. Yokoyama 2 , and Yaw-Bin Huang 2

1 Kaohsiung Medical University Hospital, Kaohsiung, TAIWAN, Taiwan, 2 Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TAIWAN, Taiwan, 3 Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TAIWAN, Taiwan, 4 National Chiao Tung University, Hsinchu, TAIWAN, Taiwan

We established a high penetration, high sensitivity infrared-fluorescent protein(IFP) for fluorescent imaging and synthesized the relatively high temporal and spatial resolution MR sensing contrast agent (SCA):]-galactosidase(]-gal) MR probe for producing the MR molecular imaging with a dual-imaging reporter animal model. The modality was used to verify the role of HOXA gene subfamily in gastric cancer development .It might also be useful in evaluating the effects of various therapeutic approaches. Because of the advantages offered by a combination of optical and MR images, it is hopeful that this technique will move quickly from in vitro and animal study to clinical trials.

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