Abstract #3810
In vivo molecular imaging using a dual-imaging reporter gene for verifying the role of HOXA gene subfamily in gastric cancer development and therapeutic monitoring
Chiao-Yun Chen 1,2 , Twei-Shiun Jaw 1,2 , Deng-Chyang Wu 2,3 , Yun-Ming Wang 4 , Gin-Chung Liu 1,2 , Kazunari K. Yokoyama 2 , and Yaw-Bin Huang 2
1
Kaohsiung Medical University Hospital,
Kaohsiung, TAIWAN, Taiwan,
2
Faculty
of Medicine, College of Medicine, Kaohsiung Medical
University, Kaohsiung, TAIWAN, Taiwan,
3
Kaohsiung
Municipal Hsiao-Kang Hospital, Kaohsiung, TAIWAN,
Taiwan,
4
National
Chiao Tung University, Hsinchu, TAIWAN, Taiwan
We established a high penetration, high sensitivity
infrared-fluorescent protein(IFP) for fluorescent
imaging and synthesized the relatively high temporal and
spatial resolution MR sensing contrast agent (SCA):]-galactosidase(]-gal)
MR probe for producing the MR molecular imaging with a
dual-imaging reporter animal model. The modality was
used to verify the role of HOXA gene subfamily in
gastric cancer development .It might also be useful in
evaluating the effects of various therapeutic
approaches. Because of the advantages offered by a
combination of optical and MR images, it is hopeful that
this technique will move quickly from in vitro and
animal study to clinical trials.
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