Abstract #3812
19 F MRI for non-invasive imaging of treatment failure in microencapsulated pancreatic cell therapy
Dian R. Arifin 1,2 , Deepak Kadayakkara 1,2 , and Jeff W.M. Bulte 1,2
1
Russell H. Morgan Radiology and Radiological
Science, Johns Hopkins University School of Medicine,
Baltimore, MD, United States,
2
Institute
for Cell Engineering, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
We developed fluorine-labeled alginate microcapsules (fluorocapsules)
for protection of transplanted pancreatic cells against
immunorejection. Our goal is to assess the feasibility
of
19
F
MRI to non-invasively visualize the degradation of
fluoroencapsulated cell grafts, and therefore the
impending failure of cell therapy in the case of capsule
rupture. We successfully demonstrated that the release
and dissipation of the fluorine agent upon capsule
rupture could be detected as a reduction in
19
F
MR signal. This corresponded to a decrease in cell
viability, indicating that
19
F
MRI can be used as a surrogate marker to predict
therapeutic success or failure.
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