Abstract #3813
Sequential and Time-lapse MRI Monitoring of Peripheral Macrophage Recruitment and Migration in Mouse Brain
Yuki Mori 1,2 , Ting Chen 1 , Koji Ohno 3 , Shinichi Yoshida 4 , Yoshiyuki Tago 4 , Tetsuya Fujisawa 5 , Yuuto Kashiwagi 1 , Masaki Fukunaga 1,2 , Yutaka Komai 6 , Yutaka Hata 5 , and Yoshichika Yoshioka 1,2
1
Biofunctional Imaging, Immunology Frontier
Research Center (IFReC), Osaka University, Suita, Osaka,
Japan,
2
Center
for Information and Neural Networks (CiNet), National
Institute of Information and Communications Technology
(NICT) and Osaka University, Suita, Osaka, Japan,
3
Institute
for Chemical Research, Kyoto University, Uji, Kyoto,
Japan,
4
Frontier
Biochemical and Medical Research Laboratories, Kaneka
Corporation, Takasago, Hyogo, Japan,
5
Graduate
School of Engineering, University of Hyogo, Himeji,
Hyogo, Japan,
6
Single
Molecule Imaging, IFReC, Osaka University, Suita, Osaka,
Japan
Combination of MRI and nanoparticles has a possibility
for visualizing the dynamics of cells in mouse brain. In
this study, we focused on peripheral macrophages and
attempted to track them noninvasively. We also attempted
to monitor dynamic behaviors of cell migration with
time-lapse MRI movie. MRI can successfully monitor the
recruitment of peripheral macrophages into CNS even in
normal as well as abnormal condition such as systemic
inflammation or brain ischemia. Time-lapse MRI movie may
reveal critical insights into cell behaviors that are
not readily evident by microscopy. Our technique could
contribute to reveal the mechanisms of neuro-immune
crosstalk.
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