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Abstract #3819

In vivo cellular MRI monitoring of FeO Labeled DC-based cancer vaccine for immunotherapeutic treatment of pancreatic cancer

Zhuoli Zhang 1 , Andrew Christian Gordon 1 , Weiguo Li 1 , Yang Guo 1 , Elias Gounaris 1 , Alexander Sheu 1 , Jodi Robin Nicolai 1 , Daniele Procissi 1 , and Andrew Larson 1

1 Radiology, Northwestern University, Chicago, Illinois, United States

In this work we demonstrate that iron-oxide labeled Dendritic Cells (DC), loaded with antigens, can be effectively tracked as they home in on the lymph nodes using MRI. We also correlate therapeutic response to successful targeting of DC as measured with MRI. The potential of the methods described can provide additional tools to develop DC based cancer vaccines.

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