Abstract #3820
Specificity of Multimodal molecular MR and US imaging applied to kidney tumor xenografts
Marie Poirier-Quinot 1 , Ludovic de Rochefort 1 , Ingrid Leguerney 1,2 , Sandra Robin 1,2 , Xavier Violas 3 , Luc Darrasse 1 , Rose-Marie Dubuisson 1 , Stphanie Pitre-Champagnat 1 , Philippe Robert 3 , and Nathalie Lassau 1,2
1
Univ Paris Sud, CNRS, UMR 8081, IR4M, Orsay,
France,
2
IRCIV
Gustave Roussy, Villejuif, France,
3
Guerbet,
Research, Roissy CDG Cedex, France
Evaluation of the specificity of multimodal molecular
protocol, with two different imaging techniques, US and
MRI, involving contrast agents (bubbles and iron oxide
nanoemulsion) both of them functionalized to target the
same integrin (ανβ3) in mouse xenograft tumor model of
kidney cancer is presented here. The protocol allows to
quantify the tumor size, the dynamic contrast-enhanced
DCE-US, the diffusion, the dynamic susceptibility
contrast DSC-MR during 1 hour after injection. This
methodological study could be used to follow-up
treatment response.
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