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Abstract #3820

Specificity of Multimodal molecular MR and US imaging applied to kidney tumor xenografts

Marie Poirier-Quinot 1 , Ludovic de Rochefort 1 , Ingrid Leguerney 1,2 , Sandra Robin 1,2 , Xavier Violas 3 , Luc Darrasse 1 , Rose-Marie Dubuisson 1 , Stphanie Pitre-Champagnat 1 , Philippe Robert 3 , and Nathalie Lassau 1,2

1 Univ Paris Sud, CNRS, UMR 8081, IR4M, Orsay, France, 2 IRCIV Gustave Roussy, Villejuif, France, 3 Guerbet, Research, Roissy CDG Cedex, France

Evaluation of the specificity of multimodal molecular protocol, with two different imaging techniques, US and MRI, involving contrast agents (bubbles and iron oxide nanoemulsion) both of them functionalized to target the same integrin (ανβ3) in mouse xenograft tumor model of kidney cancer is presented here. The protocol allows to quantify the tumor size, the dynamic contrast-enhanced DCE-US, the diffusion, the dynamic susceptibility contrast DSC-MR during 1 hour after injection. This methodological study could be used to follow-up treatment response.

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