Abstract #3823
Assessment of the size window of tumor vascular permeability using dextran-based CEST MRI
Yuguo Li 1,2 , Kannie Chan 1,2 , Yuan Qiao 3 , Jiadi Xu 2 , Jeff Bulte 1 , Bert Vogelstein 3 , Michael McMahon 1,2 , Shibin Zhou 3 , Peter van Zijl 1,2 , and Guanshu Liu 1,2
1
Radiology, Johns Hopkins University School
of Medicine, Baltimore, MD, United States,
2
FM
Kirby center, Kennedy Krieger Institute, Baltimore, MD,
United States,
3
Ludwig
Center, Howard Hughes Medical Institute and Sidney
Kimmel Cancer Center, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Assessing tumor vascular permeability has important
applications in clinical diagnosis and for the
development of personalized nanoparticulate
therapeutics. Here, we explored dextran as a potential
Chemical Exchange Saturation Transfer (CEST) imaging
agent by utilizing the CEST contrast originating from OH
protons on the glucose units. Contrast was studied for
particle sizes ranging from 4-60 nm. Dextrans of
different molecular weights could be readily detected
using CEST MRI. The differential permeability of an
experimental tumor to dextrans sized at 4 and 14 nm was
detected and renal clearance of the agents was also
monitored.
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