Abstract #3824
Generating Positive Contrast from Magnetic Nanoparticles Using a SubShortTE Method with Conventional Spin Echo Sequences
Xiaodong Zhong 1 , Liya Wang 2,3 , Jing Huang 2,3 , and Hui Mao 2,3
1
MR R&D Collaborations, Siemens Healthcare,
Atlanta, GA, United States,
2
Radiology
and Imaging Sciences, Emory University School of
Medicine, Atlanta, GA, United States,
3
Center
for Systems Imaging, Emory University School of
Medicine, Atlanta, GA, United States
This study demonstrates a new method of SubShortTE, i.e.
subtraction of a later echo signal from an earlier echo
signal, with widely available SE/TSE sequences for
generating positive contrast from magnetic nanoparticle
contrast agents. This approach was evaluated with
theoretical simulation and phantom imaging using iron
oxide nanoparticles (IONP) with different sizes and
concentrations. The results demonstrated that positive
contrast could be obtained in IONP phantoms using this
approach. SubShortTE could potentially provide a robust
alternative method to the other positive contrast
methods for molecular imaging and cell tracking
applications without the need of any special sequences.
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