Infarct size and extracellular matrix remodelling quantification using an elastin specific contrast agent (ESMA) in a model of permanent coronary ligation

Dynamic contrast-enhanced MRI (DCE-MRI) plays an increasingly important role in cardiac imaging . The dynamics of contrast agent uptake and distribution have shown high sensitivity and specificity for many pathological changes that are not detectable by anatomical imaging. Magnevist Gd-DTPA is one of the most used clinically approved contrast agents able to differentiate areas of burden from healthy after myocardial infarction (MI). Despite being an optimal tool to delineate the extent of infarction areas, Magnevist does not provide any insight about remodeling processes. For this reason, the albumin contrast agent gadofosveset, trade name Vasovist (from Ablavar), is used in this work to evaluate similarities and advantages to Magnevist in an MI mouse model at 7T.

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