Abstract #3828
Sub-5 nm Ultrafine Iron Oxide Nanoparticles for Tumor Imaging: Novel Contrast and Improved Tumor Uptake
Liya Wang 1,2 , Jing Huang 1,2 , Xiaodong Zhong 3 , Hui Wu 1,2 , Lily Yang 4 , and Hui Mao 1,2
1
Radiology and Imaging Sciences, Emory
University School of Medicine, Atlanta, Georgia, United
States,
2
Center
for System Imaging, Emory University School of Medicine,
Atlanta, Georgia, United States,
3
MR
R&D Collaborations, Siemens Healthcare, Atlanta,
Georgia, United States,
4
Surgery,
Emory University School of Medicine, Atlanta, Georgia,
United States
This study demonstrated the application of novel sub-5
nm ultra-fine iron oxide (UFIO) nanoparticles in imaging
of xenograft tumors. The results showed higher tumor
uptake of UFIO nanoparticles comparing to iron oxide
nanoparticles (IONPs) with larger sizes, suggesting that
the penetration and accumulation of IONPs in tumor
tissue is size dependent. The transition from T1
contrast in the tumor vasculature in the early phase of
post-injection to the T2 contrast at later phase, i.e.,
24 hours after the injection of UFIO nanoparticles may
provide a novel capability for following a dynamic
process of delivery of UFIO probes to the tumor.
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