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Abstract #3834

Molecular MRI and DCE-US to evaluate anti-angiogenic therapies in kidney tumor xenografts

Ludovic de Rochefort 1 , Ingrid Leguerney 1 , Marie Poirier-Quinot 1 , Sandra Robin 1 , Xavier Violas 2 , Rose-Marie Dubuisson 1 , Stphanie Pitre-Champagnat 1 , Luc Darrasse 1 , Philippe Robert 2 , and Nathalie Lassau 1

1 IR4M, Univ. Paris-Sud, CNRS, UMR 8081, Orsay, France, 2 Experimental Imaging, MRI unit, Research Division, Guerbet, Aulnay-sous-bois, France

A multimodal molecular MRI and DCE-US protocol was applied in kidney tumor xenograft in mice to follow up the response to anti-angiogenic treatments. Imaging was performed at D0 and D3 after monoclonal anti-body, tyrosine kinase inhibitor and m-Tor inhibitor administration. Tumor growth, perfusion (US), diffusion, first pass enhancement (1 min) and late enhancement (1 hour) of a targeted 3 contrast agent (MRI) were quantified. Tumor growth was reduced with treatments. Differences were observed in apparent diffusion coefficient, targeted contrast agent clearance and fixation in the different groups after treatment.

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