Abstract #3835

Soluble Gd(III)DOTA adducts with Multiwalled Carbon Nanotubes as novel contrast agents for Diffusion Tensor Imaging

Viviana Negri ^1,2 , Daniel Calle ³ , Piedad Ros ⁴ , Sebastian Cerdn ³ , and Paloma Ballesteros ²

¹ CSIC, Instituto de Investigaciones Biomdicas "A.Sols"-CSIC, Madrid, Madrid, Spain, ² Laboratorio de Sntesis Orgnica e Imagen Molecular por Resonancia Magntica, Facultad de Ciencia, UNED, Madrid, Madrid, Spain, ³ Departamento de Modelos Experimentales de Enfermedades Humanas, CSIC, Instituto de Investigaciones Biomdicas "A.Sols"-CSIC, Madrid, Madrid, Spain, ⁴ Departamento de Farmacia y Biotecnologa, Universidad Europea de Madrid, Madrid, Madrid, Spain

We describe a new generation of highly soluble, paramagnetically labeled multiwall CNTs (MWCNTs) with Gd(III)DOTA monoamide-like functionalized with a pyrene moiety, linked to the CNT through lower case Greek pi

stacking interactions. In particular, we report on the synthesis, MRI studies (ADC, T1, T2) and fluorescence emission spectra of these lower case Greek pi

stacking MWCNTs-pyrene DOTAma adducts. We synthesized two different lower case Greek pi

stacking adducts MWNTs-Gd(III)DOTAmaPyrene and MWNTs-Gd(III)DOTAmaEtDiaminePyrene, shown to be highly water soluble and to induce anisotropic diffusion of water, due to alignment of the magnetic nanotubes along the B0 axis. These derivatives are also potential fluorescence probes yielding a novel multimodal imaging platform.

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