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Abstract #3837

Contrast agents with chelated lanthanoid ions for 19F MR imaging

Vt Herynek 1 , Marie Martiniskov 2 , Andrea Glisov 1 , Jan Kotek 2 , Daniel Jirk 1 , and Milan Hjek 1

1 Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2 Faculty of Science, Charles University, Prague, Czech Republic

19F MRI is potentially an interesting tool for diffusion or perfusion measurements, and for cell tracking. It requires biocompatible and non-toxic contrast agents with high fluorine ion concentration with suitable relaxation times. We synthesized and tested both in vitro and in vivo probes based on DOTP chelates with 12 equivalent fluorine ions and a lanthanoid ion, which substantially shortens relaxation times. Measuring sequences were optimized for each chelated lanthanoid.

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