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Abstract #3838

Comparison of 3T and 14T MRI in a rat antigen-induced arthritis model.

Lindsey Alexandra Crowe 1 , Nicolas Kunz 2 , Iris Friedli 1 , Azza Gramoun 1 , Kerstin Grosdemange 1 , Lionel Maurizi 3 , Geraldine Coullerez 3 , Marie-Gabrielle Beuzelin 3 , Rolf Gruetter 2 , Heinrich Hofmann 3 , and Jean-Paul Valle 1

1 Radiology, Geneva University Hospitals, Geneva, Switzerland, 2 Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 3 Powder Technology Laboratory, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

The use of iron oxide nanoparticles in MRI is leading development of image acquisition and analysis techniques to accurately localize uptake and persistence of such contrast agents. Detailed localization of the SPION and its contrast to other structures that are also hypointense is important. We explore the advantages of high field and high resolution MRI to assess inflammation, macrophage uptake and bone erosion in an antigen-induced arthritis (AIA) model.

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