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Abstract #3862

High Concentration Gadolinium-Based Contrast Reagent Transverse Relaxivities in ex vivo Physiologic Whole Blood and Plasma at 1.5T and 3.0T

Gregory J. Wilson 1 , Charles S. Springer, Jr. 2 , Mark Woods 2,3 , Sarah Bastawrous 1,4 , Puneet Bhargava 1,4 , and Jeffrey H. Maki 1,4

1 Radiology, University of Washington, Seattle, WA, United States, 2 Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States, 3 Chemistry, Portland State University, Portland, OR, United States, 4 Radiology, Puget Sound VA HCS, Seattle, WA, United States

1 H 2 O transverse R 2 and R 2 * relaxation rate constants were measured for gadoteridol, gadobutrol, gadobenate, and gadofosveset concentrations of 0 to 18 mM in oxygenated whole blood and plasma. These values can be used to predict signal intensity during passage of an arterial bolus for contrast-enhanced MRA. R 2 * values are elevated in whole blood, likely as a result of static dephasing. Exclusion of the contrast reagents from red blood cells creates microscopic gradients in bulk magnetic susceptibility, resulting in fast dephasing of 1 H 2 O signal in whole blood.

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