Abstract #3862
High Concentration Gadolinium-Based Contrast Reagent Transverse Relaxivities in ex vivo Physiologic Whole Blood and Plasma at 1.5T and 3.0T
Gregory J. Wilson 1 , Charles S. Springer, Jr. 2 , Mark Woods 2,3 , Sarah Bastawrous 1,4 , Puneet Bhargava 1,4 , and Jeffrey H. Maki 1,4
1
Radiology, University of Washington,
Seattle, WA, United States,
2
Advanced
Imaging Research Center, Oregon Health and Science
University, Portland, OR, United States,
3
Chemistry,
Portland State University, Portland, OR, United States,
4
Radiology,
Puget Sound VA HCS, Seattle, WA, United States
1
H
2
O transverse R
2
and
R
2
* relaxation rate constants were measured
for gadoteridol, gadobutrol, gadobenate, and
gadofosveset concentrations of 0 to 18 mM in oxygenated
whole blood and plasma. These values can be used to
predict signal intensity during passage of an arterial
bolus for contrast-enhanced MRA. R
2
* values
are elevated in whole blood, likely as a result of
static dephasing. Exclusion of the contrast reagents
from red blood cells creates microscopic gradients in
bulk magnetic susceptibility, resulting in fast
dephasing of
1
H
2
O
signal in whole blood.
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