Abstract #3904
Quantify LV rotational mechanics in Duchenne and Becker Muscular Dystrophy using MR tagging
Zhe Wang 1,2 , Meral L Reyhan 2,3 , Sarah Kahn 2 , Pierangelo Renella 2,4 , J.Paul Finn 2,3 , Nancy Halnon 5 , and Daniel B. Ennis 1,2
1
Department of Bioengineering, University of
California, Los Angeles, CA, United States,
2
Department
of Radiological Science, University of California, Los
Angeles, CA, United States,
3
Biomedical
Physics Interdepartmental Program, University of
California, Los Angeles, CA, United States,
4
Department
of Medicine (Pediatric Cardiology), Childrens Hospital
of Orange County, Orange, CA, United States,
5
Department
of Medicine (Pediatric Cardiology), University of
California, Los Angeles, CA, United States
The functional consequences of ventricular fibrosis in
pediatric patients with Duchenne or Becker muscular
dystrophy (DMD/BMD) are incompletely understood. The
objective of this study was to quantify LV rotational
mechanics using cardiac MRI tagging and relate it to the
presence of fibrosis in pediatric patients with DMD/BMD.
Our results indicate that DMD/BMD directly reduces the
magnitude of all measures of ventricular rotational
mechanics and that the presence of fibrosis in DMD/BMD
further reduces their magnitude. EF was preserved in
DMD, BMD, and DMD with fibrosis despite abnormality in
LV rotational mechanics, which may be early indicators
of ventricular dysfunction.
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