Abstract #3905
LV hemodynamic performance quantification at basal and mid-ventricular level in mice with heart failure
Magdalena Jablonska 1,2 , Urszula Tyrankiewicz 1 , Henryk Figiel 2 , and Tomasz Skorka 1
1
Department of Magnetic Resonance Imaging,
The Henryk Niewodniczanski Institute of Nuclear Physics,
Polish Academy of Sciences, Krakow, Poland,
2
Department
of Medical Physics and Biophysics, AGH University of
Science and Technology, Krakow, Poland
Considering complex cardiac structure and functional
changes during HF, the hypothesis was tested: if the LV
basal layer may exhibit diastolic perturbation earlier
then mid-ventricular one when assessed using high
time-resolved cine MR images (60 movie frames/cardiac
cycle). Cardiac function of Tgαq*44 mice with HF was
imaged (at 9.4T) and data were analyzed using piecewise
linear regression. Mice with HF exhibited altered
cardiac relaxation, filling, isovolumic relaxation and
contraction time at the basal layer that was not
observed at mid-ventricular one. Obtained data
highlighted cardiac regions that may be particularly
useful for MRI diagnosis of early stages in HF.
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