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Abstract #3905

LV hemodynamic performance quantification at basal and mid-ventricular level in mice with heart failure

Magdalena Jablonska 1,2 , Urszula Tyrankiewicz 1 , Henryk Figiel 2 , and Tomasz Skorka 1

1 Department of Magnetic Resonance Imaging, The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland, 2 Department of Medical Physics and Biophysics, AGH University of Science and Technology, Krakow, Poland

Considering complex cardiac structure and functional changes during HF, the hypothesis was tested: if the LV basal layer may exhibit diastolic perturbation earlier then mid-ventricular one when assessed using high time-resolved cine MR images (60 movie frames/cardiac cycle). Cardiac function of Tgαq*44 mice with HF was imaged (at 9.4T) and data were analyzed using piecewise linear regression. Mice with HF exhibited altered cardiac relaxation, filling, isovolumic relaxation and contraction time at the basal layer that was not observed at mid-ventricular one. Obtained data highlighted cardiac regions that may be particularly useful for MRI diagnosis of early stages in HF.

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