Abstract #3909
Delayed gadolinium enhanced MRI reveals nanotherapy-induced normalization of the vessel wall endothelium in atherosclerotic mice
Claudia Calcagno 1 , Jun Tang 1 , Laurien Hassing 1,2 , Brenda L Sanchez-Gaytan 1 , Gustav Strijkers 1,2 , Willem JM Mulder 1,2 , and Zahi A Fayad 1
1
Translational and Molecular Imaging
Institute, Icahn School of Medicine at Mount Sinai, New
York, NY, United States,
2
Amsterdam
Medical Center, Amsterdam, The Netherlands, Netherlands
Atherosclerosis is the number one killer world-wide.
Increased permeability due to inflammation is a hallmark
of vulnerable atherosclerotic plaques, at high-risk of
causing myocardial infarction or stroke. This knowledge
has spurred interest in developing new compounds to
lower plaque inflammation, and non-invasive techniques
to quantify their efficacy. Here we examine the effects
on vessel wall permeability of a previously developed
drug-loaded lipoprotein nanoparticle ([S]-rHDL) with
known potent anti-inflammatory effects. We demonstrate
that this compound lowers aortic plaque permeability in
atherosclerotic ApoE-KO mice, as determined by in vivo
Gd-DTPA enhanced MRI, and as validated by ex vivo EB
NIRF imaging.
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