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Abstract #3910

Monitoring of endothelial permeability and plaque progression in a rabbit model of atherothrombosis using an albumin-binding MR contrast agent

Alkystis Phinikaridou 1 , Marcelo K Andia 2 , Prakash Saha 1 , Alberto Smith 1 , and Rene M Botnar 1

1 King's College London, London, United Kingdom, 2 Pontificia Universidad Catolica de Chile, Santiago, Chile

Endothelial dysfunction, characterized by increased vascular permeability and impaired endothelial-dependent vasodilation, precedes and portends the development of atherosclerosis. MRI studies have shown that impaired focal endothelial dysfunction correlates with the extent of focal plaque burden in the coronary arteries. We have also reported that gadofosveset, an albumin-binding MR contrast agent, can be used to non-invasively assess endothelial permeability, plaque burden progression and regression in a murine model of accelerated atherosclerosis. To expand our previous findings we investigated the interplay between endothelial dysfunction, plaque progression and instability in a bigger animal (rabbit) model of accelerated disease.

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