3D dynamic contrast enhanced (DCE) MRI of atherosclerotic plaques: image quality, temporal stability and ex vivo validation in a rabbit model
Claudia Calcagno 1 , Mark E Lobatto 1 , Philip M Robson 1 , Olivier Lairez 1 , Max Senders 1 , Alexandra Black 1 , Sarayu Ramachandran 1 , Willem JM Mulder 1,2 , Venkatesh Mani 1 , and Zahi A Fayad 1
Translational and Molecular Imaging
Institute, Icahn School of Medicine at Mount Sinai, New
York, NY, United States,
Medical Center, Amsterdam, The Netherlands, Netherlands
Abundant, permeable microvasculature is a hallmark of
high-risk atherosclerotic plaques, and can be quantified
using non-invasive 2D dynamic contrast enhanced (DCE)
MRI. Current 2D DCE-MRI acquisitions suffer from several
limitations. Here we compare 3D turbo field echo (TFE)
and turbo spin echo (TSE) DCE-MRI with extensive spatial
coverage in atherosclerotic rabbits. We find that 3D TFE
DCE-MRI has higher temporal stability than 3D TSE DCE-MRI,
and allows for comparable vessel wall/lumen delineation.
Furthermore we find that in vivo permeability by 3D TFE
DCE-MRI correlates significantly with ex vivo
permeability by ex vivo Evans Blue fluorescence.
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