Abstract #3916
Longitudinal relaxation time and apparent diffusion coefficient in human carotid plaque at 3T: phantom validation and histological comparison
Hideki Ota 1 , Mika Watanabe 2 , Tatsuo Nagasaka 3 , Makoto Obara 4 , and Hajime Tamura 5
1
Diagnostic Radiology, Tohoku University
Hospital, Sendai, Miyagi, Japan,
2
Pathology,
Tohoku University Hospital, Sendai, Miyagi, Japan,
3
Radiology,
Tohoku University Hospital, Sendai, Miyagi, Japan,
4
Philips
Electronics Japan, Tokyo, Japan,
5
Health
Sciences, Tohoku University Graduate School of Medicine,
Sendai, Miyagi, Japan
We optimized a 3-dimensional double-angle Look-Locker
and outer volume suppression diffusion weighted imaging
sequences to quantify longitudinal relaxation rate (R1)
and apparent diffusion coefficient (ADC) of human
carotid plaque components. We measured R1 and ADC of
histologically-confirmed plaque components such as lipid
core, hemorrhage and fibrous tissue. Our result
indicated that the combination of R1 and ADC enabled
objective segmentation of carotid plaque components.
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