Studying the interplay between atherosclerosis and deep vein thrombosis in a murine model using an elastin-binding contrast agent

Venous thrombosis and atherosclerosis are common conditions that together cause significant morbidity and mortality worldwide. Recent evidence suggests that venous thrombosis increases the risk of myocardial infarction and stroke, which persists for many years following the thrombotic event. In the current work, we sought to use an experimental model of atherosclerosis and deep vein thrombosis to investigate the link between plaque growth and venous thrombosis using an elastin-specific MR contrast agent in a longitudinal fashion.

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