Abstract #3942
3D Fractal Analysis of Pulmonary MRA distinguishes Pulmonary Arterial Hypertension Patients from Normal Volunteers
Phillip Kilgas 1 , Eric Schrauben 2 , Alejandro Roldan-Alzate 1 , Oliver Wieben 2 , Naomi Chesler 3 , Christopher Franois 1 , and Mark L. Schiebler 1
1
Radiology, UW-Madison, Madison, WI, United
States,
2
Medical
Physics, UW-Madison, Madison, WI, United States,
3
Biomedical
Engineering, UW-Madison, Madison, WI, United States
Pulmonary arterial hypertension (PAH) is a rapidly
progressive disease. As a result of elevated pulmonary
arterial pressures, pruning of the number of small
pulmonary artery occurs [1]. Quantification of this
pruning may provide a biomarker independent of vessel
size for this disease and could lessen the need for
invasive catheter based measurements. We have found that
3D fractal analysis of the pulmonary arterial branching
pattern, derived from MRA examinations, is an
independent variable that can be used to diagnose the
presence of pulmonary arterial hypertension.
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