Abstract #3943
Aberrant Myocardial Sheetlet Orientation in Hypertrophic Cardiomyopathy detected using In Vivo Cardiovascular Magnetic Resonance Diffusion Tensor Imaging
Pedro Ferreira 1 , Philip Kilner 2 , Laura-Ann McGill 1 , Sonia Nielles-Vallespin 3 , Andrew Scott 1 , Bruce Spottiswoode 4 , Xiaodong Zhong 5 , Siew Ho 6 , Karen McCarthy 6 , Tevfik Ismail 1 , Peter Gatehouse 1 , Ranil de Silva 2 , Alexander Lyon 1 , Sanjay Prasad 2 , David Firmim 2 , and Dudley Pennell 1
1
NIHR cardiovascular BRU, Royal Brompton
Hospital, London, London, United Kingdom,
2
Cardiovascular
Magnetic Resonance Unit, Royal Brompton Hospital,
London, United Kingdom,
3
National
Institutes of Health, MD, United States,
4
Siemens
Healthcare, IL, United States,
5
Siemens
Healthcare, GA, United States,
6
Royal
Brompton Hospital, London, United Kingdom
Cardiac Diffusion Tensor Imaging (cDTI) provides
information on cross-myocyte components of
intramyocardial water diffusion with the
secondary-eigenvector (E2). Assuming these to be
constrained by the sheetlet and shear-layer
microstructure of left ventricular myocardium, we
investigated if in vivo cDTI could identify changing
sheetlet orientations and abnormalities in hypertrophic
cardiomyopathy (HCM). We also investigated the impact of
myocardial strain correction on the measured sheetlets
orientation. Myocardial strain correction results in
substantial changes in the orientation of E2.
Nevertheless, with or without strain correction, E2 is
more wall-perpendicular in HCM, which is in keeping with
the sheetlet orientation expected in hyper-contracted
myocardium.
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