Noninvasive assessment of cardiomyocyte breadth from extracellular volume fraction with MRI
Shi-Jun Zhang 1 , Jiyang Jin 1 , Min Chen 1 , Lin Wang 1 , Andreas Greiser 2 , and Shenghong Ju 1
Department of Radiology, Zhongda Hospital,
Southeast University, Nanjing, Jiangsu Province, China,
AG Healthcare Sector, Bayern, Germany
The myocardial extracellular volume fraction (ECV) is a
reflection of the relative volume of the extracellular
space and cells in myocardium, and we infer that the
size of the cardiomyocytes affects ECV and in the other
hand could be reflected by ECV. We found through the
present study of swine that ECV correlates negatively
with cardiomyocyte breadth under physiological
conditions, indicating ECV might be a potential MRI
biomarker for cardiomyocyte size estimation in vivo.
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