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Abstract #3973

Microstructural Characterization of the Infarct Border Zone in Humans with In Vivo Diffusion Tensor MRI and Gray-Zone Late Gadolinium Enhancement

Choukri Mekkaoui 1 , Christian T Stoeck 2 , Marcel P Jackowski 3 , Timothy G Reese 4 , Sebastian Kozerke 5 , and David E Sosnovik 6

1 Harvard Medical School - Massachusetts General Hospital, Boston, MA, United States, 2 University and ETH Zurich, zurich, Switzerland, 3 University of So Paulo, So Paulo, Brazil, 4 Athinoula A Martinos center for Biomedical imaging, Boston, United States, 5 University and ETH Zurich, Zurich, Switzerland, 6 Harvard Medical School - Massachusetts General Hospital, Boston, United States

The infarct border zone plays a major role in the development of mechanical and electrical dysfunction during post-infarction remodeling. We used in vivo diffusion tensor MRI (DTI) and late gadolinium enhancement (LGE) in patients with recent myocardial infarctions to examine the properties of the infarct border zone. We show that an increase in LGE in the border zone of just 1 standard deviation above normal is associated with significant microstructural abnormality, including marked heterogeneity of myofiber tract orientation and loss of tract coherence.

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