Abstract #3972
Optimization of Post Contrast T1 Mapping Time for Diagnostic Assessment of Myocardial Amyloid
Mitchell Anthony Cooper 1 , Thanh D. Nguyen 2 , Jonathan Weinsaft 3 , Matthew Maurer 4 , Suzanne Lentzsch 4 , Heather Landau 5 , Jiwon Kim 5 , Sattar Gojraty 3 , Silvina Dutruel 2 , Martin Prince 2 , and Yi Wang 2
1
Biomedical Engineering, Cornell University,
Ithaca, New York, United States,
2
Radiology,
Weill Cornell Medical College, New York, NY, United
States,
3
Cardiology, Weill Cornell Medical
College, New York, New York, United States,
4
Columbia
University, New York, New York, United States,
5
Memorial
Sloan Kettering Cancer Center, New York, New York,
United States
Cardiac amyloidosis is a serious condition in which
insoluble proteins accumulate in the extracellular space
of the myocardium, resulting in impaired cardiac
function. The current gold standard for the evaluation
of cardiac involvement is endomyocardial biopsy, an
invasive procedure not well suited for screening
purposes or serial assessment. Myocardial T1 mapping
after the administration of a Gadolinium (Gd) contrast
agent, which acts as a diffusible tracer, has emerged as
a viable noninvasive tool to detect amyloid infiltration
and to quantify changes in the extravascular
extracellular volume (ECV) in cardiac amyloidosis
(1-3).The purpose of this study was to identify the
optimal T1 mapping time by performing numerical
simulation of a tracer kinetic model as well as by
measuring myocardial T1 at various time points in
healthy and amyloid positive patients.
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