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Abstract #3981

Patient-reported Outcomes are associated with Cartilage T1ρ and T2 Quantification and Whole-Organ Magnetic Resonance Imaging Score (WORMS) after acute ACL injuries

Yu Zhang 1,2 , Michael Hoppe 1 , Samuel Wu 3 , Martin Kretzschmar 3 , Richard Souza 3 , Benjamin Ma 3 , and Xiaojuan Li 3

1 Radiology, University of California San Francisco, San Francisco, CA, United States, 2 Department of Orthopaedic Surgery, The First Hospital of Jilin University, Changchun, Jllin, China, 3 University of California San Francisco, CA, United States

Our study is to evaluate the relationship between cartilage MRI quantification, WORMS (Whole-Organ Magnetic Resonance Imaging Score) and patient-reported outcomes after acute ACL injuries. forty-two subjects with ACL acute ruptured were enrolled. T1ρ and T2 MRI scan were performed at baseline. Osteoarthritis Outcome Score (KOOS) questionnaire was filled in by each patient during the MR visit and WORMS score was graded by experienced msk radiologists. KOOS has significantly correlations with T1ρ and T2 quantification in some compartments of cartilage in tibia and Femoral condyle, and with several sub-scores in WORMS, such as cartilage lesion and bone marrow edema. Significant correlations were observed between KOOS and cartilage T1ρ and T2 after adjusted for age, BMI and time to injury, indicating an independent relationship between cartilage damage and patient outcomes after acute injuries. Higher WORMS scores on cartilage lesion and bone marrow edema, especially on lateral side of knee joint, are obviously related with worse patients outcome. It revealed that the recovery of lateral focal lesion potentially greatly affected the patients daily living quality.

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