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Abstract #3985

Evaluation of the GAG content of articular cartilage in the knee joint using gagCEST: correlation to the gold-standard with multicompartmental biochemically analyzed GAG content

Martin Brix 1,2 , Vladimir Mlynarik 2 , Benjamin Schmitt 3 , Pavol Szomolanyi 2 , Gerhard Hobusch 1 , Florian Sevelda 1 , Stephan Puchner 1 , Sonja Walzer 1 , Reinhard Windhager 1 , Stephan Domayer 4 , and Siegfried Trattnig 2

1 Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 2 High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3 Siemens Australia, Australia, 4 Sonderkrankenanstalt Zicksee, Austria

The purpose of this study was the comparison of biochemically determined GAG content in knee joints of human cadavers to gagCEST values. Therefore, the condyles of four human cadavers were measured using gagCEST. From each condyle, nine biopsies were taken from a medial and lateral compartment and the GAG content was measured in the lab. Regions of interest were drawn manually corresponding to the biopsy areas. A correlation coefficient of r = 0.863 was observed (p < 0.001). The excellent correlation between the MTRasym and cartilage GAG content demonstrates the feasibility of the technique.

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