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Abstract #4006

Quantitative NMRI and NMRS indices identify augmented disease progression after loss of ambulation in forearms of boys with Duchenne Muscle Dystrophy

Claire Wary 1 , Noura Azzabou 1 , Cline Giraudeau 1 , Julien Le Lour 1 , Thomas Voit 2 , Laurent Servais 3 , and Pierre G Carlier 1

1 AIM-CEA Institut de Myologie, Laboratoire RMN, Paris, France, 2 Institut de Myologie, Universit Pierre et Marie Curie Paris 6, UM 76, INSERM U974, CNRS UMR 7215, Paris, France, 3 AIM, Service Essais Cliniques et Bases de Donnes, Paris, France

Twelve quantitative NMRI and NMRS indices were measured to evaluate disease progression in forearms of 24 Duchenne Muscular Dystrophy patients. Fat infiltration and muscle T2 showed greater involvement in flexor compared to extensor muscle groups, however, while fat fraction increased, muscle T2 became lower in non ambulant patients. Fat infiltration and metabolic indices measured in arms of patients correlated strongly together, but not with T2, and worsened overall with patient age. However these indices evolved remarkably differently before and after loss of ambulation, evocative of concomittant progression in lower and upper limbs.

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