Abstract #4006
Quantitative NMRI and NMRS indices identify augmented disease progression after loss of ambulation in forearms of boys with Duchenne Muscle Dystrophy
Claire Wary 1 , Noura Azzabou 1 , Cline Giraudeau 1 , Julien Le Lour 1 , Thomas Voit 2 , Laurent Servais 3 , and Pierre G Carlier 1
1
AIM-CEA Institut de Myologie, Laboratoire
RMN, Paris, France,
2
Institut
de Myologie, Universit Pierre et Marie Curie Paris 6,
UM 76, INSERM U974, CNRS UMR 7215, Paris, France,
3
AIM,
Service Essais Cliniques et Bases de Donnes, Paris,
France
Twelve quantitative NMRI and NMRS indices were measured
to evaluate disease progression in forearms of 24
Duchenne Muscular Dystrophy patients. Fat infiltration
and muscle T2 showed greater involvement in flexor
compared to extensor muscle groups, however, while fat
fraction increased, muscle T2 became lower in non
ambulant patients. Fat infiltration and metabolic
indices measured in arms of patients correlated strongly
together, but not with T2, and worsened overall with
patient age. However these indices evolved remarkably
differently before and after loss of ambulation,
evocative of concomittant progression in lower and upper
limbs.
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