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Abstract #4007

T 2 mapping and Single Voxel 1 H-MRS Detect Skeletal Muscle Involvement in Young Boys with Duchenne Muscular Dystrophy

Sean C Forbes 1 , Glenn A. Walter 1 , William Rooney 2 , Dah-Jyuu Wang 3 , William Triplett 1 , Rebecca Willcocks 1 , James Pollaro 2 , Barry Byrne 1 , Richard Finkel 4 , Barry Russman 5 , Erika Finanger 5 , Gihan Tennekoon 3 , Lee Sweeney 6 , and Krista Vandenborne 1

1 University of Florida, Gainesville, Florida, United States, 2 Oregon Health & Science University, Portland, Oregon, United States, 3 Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 4 Nemours Childrens Hospital, Florida, United States, 5 Shriners Hospital for Children, Portland, Oregon, United States, 6 University of Pennsylvania, Philadelphia, Pennsylvania, United States

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle deterioration, loss of functional abilities, and reduced life expectancy. Functional deficits in muscle performance are often not observed in DMD until after age 7, and therefore these functional measures may not be sensitive for detecting disease progression at a young age. In this study we observed that MRI-T 2 and 1 H 2 O T 2 derived using 1 H-MRS were sensitive to muscle involvement at a young age (5-7 years) consistent with increased inflammation and muscle damage in DMD.

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