Abstract #4007
T 2 mapping and Single Voxel 1 H-MRS Detect Skeletal Muscle Involvement in Young Boys with Duchenne Muscular Dystrophy
Sean C Forbes 1 , Glenn A. Walter 1 , William Rooney 2 , Dah-Jyuu Wang 3 , William Triplett 1 , Rebecca Willcocks 1 , James Pollaro 2 , Barry Byrne 1 , Richard Finkel 4 , Barry Russman 5 , Erika Finanger 5 , Gihan Tennekoon 3 , Lee Sweeney 6 , and Krista Vandenborne 1
1
University of Florida, Gainesville, Florida,
United States,
2
Oregon
Health & Science University, Portland, Oregon, United
States,
3
Children's
Hospital of Philadelphia, Philadelphia, Pennsylvania,
United States,
4
Nemours
Childrens Hospital, Florida, United States,
5
Shriners
Hospital for Children, Portland, Oregon, United States,
6
University
of Pennsylvania, Philadelphia, Pennsylvania, United
States
Duchenne muscular dystrophy (DMD) is characterized by
progressive muscle deterioration, loss of functional
abilities, and reduced life expectancy. Functional
deficits in muscle performance are often not observed in
DMD until after age 7, and therefore these functional
measures may not be sensitive for detecting disease
progression at a young age. In this study we observed
that MRI-T
2
and
1
H
2
O
T
2
derived using
1
H-MRS
were sensitive to muscle involvement at a young age (5-7
years) consistent with increased inflammation and muscle
damage in DMD.
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