Abstract #4008
MR supports therapeutic effects of corticosteroids in 5-7 year old boys with DMD
Ishu Arpan 1 , Rebecca Willcocks 1 , Sean Forbes 1 , Donovan Lott 1 , Claudia Senesac 1 , William Triplett 1 , Michael Daniels 2 , Barry Byrne 3 , Bill Rooney 4 , Erika Finanger 4 , Richard Finkel 5 , Barry Russman 4,6 , Gihan Tennekoon 5 , Dah-Jyuu Wang 7 , Glenn Walter 8 , H. Lee Sweeney 9 , and Krista Vandenborne 1
1
Physical Therapy, University of Florida,
Gainesville, Florida, United States,
2
University
of Texas, Texas, United States,
3
Pediatrics
and Molecular Genetics & Microbiology, University of
Florida, Gainesville, Florida, United States,
4
Oregon
Health & Science University, Oregon, United States,
5
Neurology,
The Childrens Hospital of Philadelphia, Pennsylvania,
United States,
6
Shriners
Hospital for Children, Oregon, United States,
7
Radiology,
The Childrens Hospital of Philadelphia, Pennsylvania,
United States,
8
Physiology
and Functional Genomics, University of Florida,
Gainesville, Florida, United States,
9
Physiology,
University of Pennsylvania, Pennsylvania, United States
The aim of this study was to evaluate impact of
corticosteroids on lower extremity muscles of 5-7 year
old boys with DMD using MRI and MRS. 15 boys with DMD on
corticosteroids and 15 age-matched corticosteroid-naive
boys were recruited. Inherent MR relaxation properties
of muscle (T
2
by
imaging and spectroscopy) and lipid fraction were
measured. MRI/MRS results showed that T
2
values
and fat fraction were lower in muscles of boys in
treatment group; suggesting reduced inflammation/ damage
and fat infiltration with corticosteroid treatment.
Further, there was less change in fat fraction over one
year in muscles of boys taking corticosteroids.
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