Abstract #4009
Multi-parametric Classification of Inflammatory Myopathies at 3.0 T
Ke Li 1,2 , Richard D. Dortch 1,2 , E. Brian Welch 1,2 , Susan F. Kroop 3 , Joseph W. Huston 3 , Amanda K.W. Buck 1,2 , Theodore F. Towse 2,4 , Nathan D. Bryant 1,2 , Bruce M. Damon 1,2 , and Jane H. Park 5
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
2
Department
of Radiology, Vanderbilt University, Nashville, TN,
United States,
3
Rheumatology
Division, School of Medicine, Vanderbilt University,
Nashville, TN, United States,
4
Physical
Medicine and Rehabilitation, Vanderbilt University,
Nashville, TN, United States,
5
Molecular
Physiology and Biophysics, Vanderbilt University,
Nashville, TN, United States
The idiopathic inflammatory myopathies (IIM), including
polymyositis, dermatomyositis, and inclusion body
myositis, are a set of chronic disorders with
pathological features of muscle inflammation, fibrosis,
fat infiltration/replacement, and atrophy. IIM patients
experience weakness, pain, fatigue, and difficulties in
daily activities. However, clear no correlations have
been established between the variations in clinical
presentation of these diseases, degree of muscle enzyme
elevation, and degree of weakness are not always
present. In this work, a multi-parametric MRI protocol
was developed to investigate the pathological processes
at a microscopic level and to characterize the severity
of muscle pathologies more objectively and
quantitatively.
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