Abstract #4010

ROLE OF MACROPHAGIC HIFs IN THE RESOLUTION OF INFLAMMATION DURING SKELETAL MUSCLE REGENERATION: A COMBINED IN VITRO, EX VIVO AND MULTIMODAL MRI INVESTIGATION

JULIEN GONDIN ¹ , GUILLAUME DUHAMEL ¹ , MARINE THERET ² , KATARINA PEGAN ³ , CAROLE PEYSSONNAUX ² , SYLVAIN CUVELLIER ² , BENEDICTE CHAZAUD ² , DAVID BENDAHAN ¹ , and REMI MOUNIER ²

¹ Aix-Marseille University, CNRS, CRMBM UMR 7339, MARSEILLE, France, ² INSERM, U1016; CNRS, UMR8104; Universit Paris Descartes, Institut Cochin, PARIS, France, ³ Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, LJUBLJANA, Slovenia

We aimed at carefully addressing the role of myeloid HIFs in the resolution of inflammation during skeletal muscle regeneration on the basis of in vitro and ex vivo experiments combined to in vivo multimodal magnetic resonance imaging (MRI), including T2 mapping and diffusion tensor imaging. Our multiscale methodological approach clearly demonstrated that neither HIF-1α nor HIF-2α are involved in the muscle regeneration process resulting from an acute injury, thereby indicating that myeloid HIFs are dispensable for skeletal muscle regeneration. We also reported that multimodal MRI appears as a method of choice for monitoring skeletal muscle injury and repair.

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