Abstract #4020
Application of a SAGE Sequence During Isometric Contractions in Skeletal Muscle
Christopher P. Elder 1,2 , Jack T. Skinner 1,3 , Theodore F. Towse 2,3 , Nathan D. Bryant 1,3 , and Bruce M. Damon 1,3
1
Vanderbilt University Institute of Imaging
Science (VUIIS), Vanderbilt University, Nashville, TN,
United States,
2
Physical
Medicine and Rehabilitation, Vanderbilt University,
Nashville, TN, United States,
3
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States
Subtracting the time-courses of R2* and R2 from separate
image acquisitions yields an estimate of R2 that can be
used for image-based calculation of muscle oxyhemoglobin
saturation. An EPI based multiple spin- and
gradient-echo (SAGE) method developed for brain
perfusion imaging permits simultaneous measurement of
R2* and R2. We applied the SAGE sequence to measurements
of relaxation rates in skeletal muscle during maximal
and submaximal isometric dorsiflexion contractions.
Baseline SAGE R2* and R2 measurements agree with
conventional multi-echo measurements. SAGE allows more
direct measurement of R2* and R2 related to the BOLD
effect in skeletal muscle induced by isometric
contractions.
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