Abstract #4021
Cross-sectional Relationships Between Muscle ATP Synthesis, Ambulatory Performance, and Age: Initial Findings from the Baltimore Longitudinal Study on Aging (BLSA)
Seongjin Choi 1 , David A. Reiter 2 , Kenneth W. Fishbein 2 , Eleanor M. Simonsick 1 , Michael Schr 3 , Richard G. Spencer 2 , and Luigi Ferrucci 1
1
Translational Gerontology Branch,
NIH/National Institute on Aging, Baltimore, MD, United
States,
2
Laboratory
of Clinical Investigation, NIH/National Institute on
Aging, Baltimore, MD, United States,
3
Philips
Healthcare, Cleveland, Ohio, United States
Gait speed has been established as the single most
important predictor of morbidity in the elderly. In
addition, muscle mitochondrial function plays a central
role in mobility. 31P MRS of skeletal muscle permits the
measurement of maximum ATP synthesis rate through the
recovery time constant of phosphocreatine (τPCr) after
exercise. In this cross-sectional study using the
Baltimore Longitudinal Study on Aging cohort, we
assessed the associations between 31P MRS-determined
mitochondrial function, age and ambulatory speed. We
found that τPCr correlated well with maximum, but not
with usual, walking speed, indicating its potential
usefulness as a marker for maximum energy output.
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